Exclusive direct rates
up to 10% less
than on Booking.com
Check rooms and rates
From209US$ /night
Check-in
29Oct2025Select date
Check-out
30Oct2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202

21C Museum Hotel Louisville is situated in a business area of Louisville, within 500 feet of Kentucky Science Center and approximately 25 minutes by foot from University of Louisville. Boasting a location next to Louisville Slugger Museum & Bat Factory, the hotel offers 96 rooms and a 24-hour bar onsite.

Location

Centrally situated in a business neighborhood, the Louisville hotel is about a 5-minute stroll from Muhammad Ali Center Museum. From the boutique-style 21C Museum Hotel it will take around 30 minutes to stroll to Schimpff's Confectionery.

The Louisville property is just beside Main / 7th bus stop.

Thomas Edison House is 25 minutes' walk away.

Rooms

The rooms at the 5-star 21C Museum Hotel Louisville have a flat-screen TV with satellite channels, along with a mini bar fridge and tea/coffee making equipment for your convenience. The rooms have elegant furniture featuring a writing desk. Offering a tub, a walk-in shower, and a separate toilet, the bathrooms are also appointed with a shower cap and bath sheets. They offer views of the urban.

Eat & Drink

While staying at the non-smoking hotel, guests can choose from dining options nearby, such as Main Eatery, located merely 100 feet away, or Walker's Exchange at a 7-minute walking distance.

Leisure & Business

Take benefit from a sauna, spa therapy, and various recreational opportunities to diversify your leisure time. Active guests will be interested in bicycle usage and bike loans arranged by the 21C Museum Hotel Louisville. Business travelers are welcome to use 17 meeting rooms and a 24-hour business center offered on site.

View all

Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Getting around

All transportation options listed – From airport shuttles to taxis and trains

City Centre
Louisville 1.9 km
Airports
Louisville (SDF) 11.9 km

Facilities

Amenities designed for comfort – Perfect for layovers & transit travelers

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Want early booking discounts?
Get special rates now!
Check Rates

Next best alternative

Consider them for your next trip.
Check-in
29Oct2025Select date
Check-out
30Oct2025Select date
Rooms and Guests2 Guests, 1 Room